Accelerating next-generation drug discovery with click-based construction of PROTACs

In 2001, chemists K. Barry Sharpless, Hartmuth C. Kolb, and M. G. Finn introduced click chemistry, a concept in which organic ...
C&EN

Cycloaddition of Phenyltriazolinedione with Carbazole-Alkynes and Yne-Carbamates to Access Diazacyclobutenes

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
C&EN

Mechanistic Studies Inform Design of Improved Ti(salen) Catalysts for Enantioselective [3 + 2] Cycloaddition

Ti(salen) complexes catalyze the asymmetric [3 + 2] cycloaddition of cyclopropyl ketones with alkenes. While high enantioselectivities are achieved with electron-rich alkenes, electron-deficient ...
Frontiers

Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions

1 Dipartimento di Scienza e Tecnologia del Farmaco and NIS, Centre for Nanostructured Interfaces and Surfaces, University of Turin, Turin, Italy 2 Center of Bioanalytical Research and Molecular Design ...