BACKGROUND: The entrance of naive T cells into lymph nodes (LNs) is a crucial step for induction of heart transplant acceptance under costimulatory blockade. Specialized blood vessels within the LN ...
Jacob Lalezari of CytoDyn shares insights about CCR5-targeting therapy for cancer, including triple negative breast cancer and colorectal cancer.
Researchers at the Ragon Institute and Scripps Research Institute have discovered that antibodies produced during immune responses act as a "brake" on B cell selection, preventing over-optimization ...
From early failures to prefusion F protein breakthroughs, RSV vaccine development has accelerated, reshaping prevention strategies for infants and older adults.
As population immunity continues to grow, understanding how immune responses influence both disease outcomes and viral evolution has become increasingly important.
Abstract: Modeling the impact of amino acid mutations on the binding affinity between antibodies and antigens plays a pivotal role in antibody therapeutics development. While numerous deep ...
Introduction: The optimization of neutralizing monoclonal antibodies (NMAbs) is crucial to counter viral evolution. The structural stability of the heavy-chain complementarity-determining region 3 (H3 ...
This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
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