A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the ...

When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life.

This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

In a phase 3, international, double-blind trial, we randomly assigned high-risk patients with atrial fibrillation in a 1:1 ratio to receive asundexian at a dose of 50 mg once daily or standard-dose ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 6).

The most important attribute of patient-centered care is the active engagement of patients when fateful health care decisions must be made — when they arrive at a crossroads of medical options, where ...

Live Attenuated Varicella Virus Vaccine — Efficacy Trial in Healthy Children. (N Engl J Med 1984;310:1409-1415). In the first paragraph of Methods (page 1409), the parenthetical in the sentence beg ...

A 23-year-old man presented with a 2-day history of painful swallowing and hoarseness. The symptoms had started immediately after he had inhaled nitrous oxide through his mouth from a hand-held can ...

Mucormycosis is a rapidly progressive, invasive fungal infection that affects patients who are severely immunocompromised, as well as patients with diabetes and persons with immunocompetence who have ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 21).

A 76-year-old man presented with a 2-day history of blood-filled blisters on the tongue. Multiple hemorrhagic bullae on the tongue and gingiva and purpura on the arms and legs were noted.