Running Linux from a USB drive is possible. You can boot just about any distribution you want from USB. There are some things you should consider before going this route. I've used Linux in just about ...
My BitLocker enabled computer won't boot without my USB.
While it's not as necessary on newer hardware, old and less capable desktops or laptops could get a helpful boost from any USB storage drives lying around.
USB flash drives are handy devices to have because of their usefulness. One obvious use case for a flash drive is, of course, storage. However, there are many extra ways to use your USB flash drive.