Cancer immunotherapy has advanced significantly in recent years, dramatically improving patient prognosis and survival. The majority of cancer immunotherapy research currently focuses on the first T ...

The interleukin-2 receptor subunit γ (IL-2RG), also known as γc cytokine receptor or CD132, family of cytokines includes interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21. These γc cytokines ...

A pleiotropic cytokine central to the regulation of T-cell responses, interleukin 2 (IL-2), plays an essential role in a huge range of other immune modulatory actions. Image Credit: Sino Biological ...

Interleukin-11 (IL-11) is an interesting and unique pleiotropic cytokine, originally characterized as a hematopoietic cytokine with thrombopoietic activity. Yet recently, IL-11 has been implicated in ...

Interleukin-12 (IL-12) is a pleiotropic cytokine designated as a cytotoxic lymphocyte maturation factor and NK cell stimulator that interconnects innate and adaptive immunity. Studies in animal models ...

Many proteins and peptides affect the growth, identity, and function of eukaryotic cells. Very often their effects are highly pleiotropic, making exact boundaries and distinctions between proteins ...

S. Akira, T. Hirano, T. Taga, T. Kishimoto, "Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)," FASEB Journal, 4:2860-67, 1990. Shizuo ...

Treatment of Relapsed Wilms’ Tumor With High-Dose Therapy and Autologous Hematopoietic Stem-Cell Rescue: The Experience at Children’s Memorial Hospital Interleukin-12 (IL-12) and interferon alfa-2b ...

Interleukin (IL-6) is a pleiotropic cytokine that has been implicated in a variety of cancers. It has been shown that IL-6 is a survival factor and is involved in the promotion of prostate cancer and ...