THE coumarin anticoagulants depress the synthesis of four clotting factors: prothrombin; proconvertin (factor VII); Stuart factor (factor X); and plasma thromboplastin component, or PTC (factor IX).
Thirteen patients with liver disease and an abnormal prothrombin time refractory to vitamin K therapy were studied (Tables 1 and 2). None of the patients were actively bleeding, and none had received ...
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