The kinetochore is a complex molecular machine that directs chromosome segregation during mitosis. It is one of the most elaborate subcellular protein structures in eukaryotes, comprising more than ...

Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is ...

Centromeres are curious structures. These specially organized chromosomal regions are best known for their unique and critical role in cell division, in which they are well understood to serve as the ...

About a third to two-thirds down the shaft of a chromosome is a constricted site called the centromere. When a chromosome replicates, the old and new pair (called chromatids) are held together at this ...

Just like you might use a belt to keep your clothes in place, the centromere holds a pair of chromatids together and attaches it to the mitotic spindle during cell division to ensure that each ...

The centromere of chromosomes plays a crucial role in cell division. Using the model plant Arabidopsis thaliana, an international team of researchers has investigated how two crucial proteins -- KNL2 ...

Probing the last genomic frontier of higher organisms, an international team of scientists has succeeded in sequencing a little understood - but critical - genetic domain in rice. MADISON - Probing ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

Researchers from the Max Planck Institute have elucidated the molecular mechanism regulating the replenishment of centromeric protein A (CENP-A) at the centromere. The study reveals how Polo-like ...

Some scientists call it the "final frontier" of our DNA -- even though it lies at the center of every X-shaped chromosome in nearly every one of our cells. It's called the centromere, and it plays a ...

O. Delattre, A. Bernard, B. Malfoy, F. Marlhens, E. Viegas-Pequignot, C. Brossard, O. Haguenauer, N. Creau-Goldberg, N'Guyen Van Cong, B. Dutrillaux and G. Thomas ...

We purified 15,000-fold from HeLa cell nuclear extract the centromere antigen that reacts specifically with the 17-bp sequence, designated previously as CENP-B box, in human centromeric α-satellite ...